NSA Panama City exists to enable warfighter readiness. The installation's largest tenant command is Naval Surface Ware Center Panama City (NSWC) Division which is one of the major research, development, test and evaluation laboratories in the Navy. NSWC boasts expertise in engineering and scientific disciplines in the areas of mine warfare, expeditionary warfare, special warfare and diving and life support. NSWC and three other tenant commands: Navy Experimental Diving Unit, Naval Diving and Salvage Training Center and Center for Navy Ordnance Disposal and Diving, together make the installation a consolidated site for all Navy diving and salvage research, development, testing and training.
Currently, NSA PC hosts many other tenant commands, including Explosive Ordnance Disposal Detachment, U.S. Coast Guard Station Panama City, Florida Fish and Wildlife Conservation Commission, Naval Branch Health Clinic Panama City,Veterans Affairs Outpatient Clinic, Navy Exchange, Naval Criminal Investigative Service, Naval Special Warfare Training Group 3 Detachment, Navy Federal Credit Union.